Investors › AI Angels › David Siegel
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David Siegel

AI angel investor
David Siegel co-founded Two Sigma and is a co-chairman of the firm. As an angel, he joined the Standard Kernel seed and has backed AI companies including Liquid AI and Samaya AI.
Artificial IntelligenceMachine LearningLife SciencesFinancial Services
Focus: Seed · Series A · AI infrastructure · Applied AI · Life sciences · Angel

About David Siegel

Background

David Siegel is a co-founder and co-chairman of Two Sigma Investments, a New York hedge fund that uses machine learning, AI and distributed computing in its trading strategies. He founded it in 2001 with John Overdeck and Mark Pickard. Crunchbase lists him as an MIT alumnus, and Wikipedia describes him as a computer science Ph.D.

Siegel and Overdeck ran Two Sigma until August 2024. Since September 30, 2024, the firm has been led by co-CEOs Carter Lyons and Scott Hoffman. Siegel and Overdeck remain co-chairmen.

Angel investing track record

Crunchbase lists five personal investments for David Siegel: Standard Kernel, Cosmos Innovation, Lumen Bioscience, Samaya AI and Liquid AI. Tracxn separately describes him as an angel investor in four startups who sits on two company boards. Crunchbase does not make the dates and amounts of most of these rounds visible, so we do not list years for them.

AI investments

His most recent AI round on the Lounge deals desk is the Standard Kernel $20M seed (March 2026). Standard Kernel is a Mountain View, CA startup building AI systems that generate GPU software. Jump Capital led the round. FinSMEs lists "David M. Siegel" among the participating angels and strategic partners, alongside Jeff Dean, Jonathan Frankle, Michael Carbin, Sachin Katti, Walden Yan, CoreWeave and Ericsson Ventures. General Catalyst, Felicis, Cowboy Ventures, Link Ventures and Essence VC also took part.

Crunchbase also shows a Series A in Samaya AI and a seed round in Liquid AI.

Investment focus

The public record shows a mix of AI infrastructure, applied AI and life sciences. Rounds range from seed to Series C. Siegel has not publicly stated a check size, a stage preference or what he looks for in founders, and we found no public statement on geography. In the Standard Kernel round he invested as an angel alongside institutional funds rather than leading.

Notable portfolio companies
  • Standard Kernel: builds AI systems that generate GPU software. Joined the $20M seed in March 2026.
  • Liquid AI: AI company. Crunchbase lists a seed round investment.
  • Samaya AI: AI company. Crunchbase lists a Series A investment.
  • Lumen Bioscience: Crunchbase lists a Series C investment.
  • Cosmos Innovation: Crunchbase lists a venture round investment.
Sources

Investing activity

David Siegel appears in 1 AI deal tracked by the Lounge deals desk, rounds totalling $20M. The rounds are mostly Seed, with a median round size of $20M. The most recent is Standard Kernel (Seed, $20M, Mar 2026).

David Siegel most often invests alongside Jump Trading, Menlo Ventures, Jeffrey Dean and General Catalyst, and the companies they back on Lounge are mostly in AI.

Deals

1
AI rounds and acquisitions David Siegel took part in, newest first.

Frequently asked questions about David Siegel

Who is David Siegel the angel investor?

David Siegel is a co-founder and co-chairman of Two Sigma Investments. Crunchbase lists him as a personal investor in five companies, including Standard Kernel, Liquid AI and Samaya AI.

Has David Siegel invested in AI startups?

Yes. He participated as an angel in the $20M Standard Kernel seed in March 2026. Crunchbase also lists Liquid AI (seed) and Samaya AI (Series A).

What is David Siegel's check size?

No check size is public. We have not found any statement from him or any announcement that gives one.

What stage does David Siegel invest in?

His listed investments span seed (Standard Kernel, Liquid AI), Series A (Samaya AI) and Series C (Lumen Bioscience). He has not stated a stage preference.

Did David Siegel lead the Standard Kernel round?

No. Jump Capital led the round. Siegel was one of several angels and strategic partners who took part.

Is David Siegel the same person as the Stripe employee with the LinkedIn handle siegel-david?

We could not confirm that. The LinkedIn profile at that handle appears to belong to a Stripe employee in Brooklyn, not the Two Sigma co-founder, so we do not link it here.

Is David Siegel an angel investor?

Yes. David Siegel invests personally as an angel.

What AI companies has David Siegel invested in?

David Siegel's AI investments include Standard Kernel. The 1 round on Lounge are listed on this page with amounts, dates and co-investors.

What stage does David Siegel invest at?

In the rounds tracked on Lounge, David Siegel has invested at Seed, with a median round of $20M.

Who does David Siegel co-invest with?

David Siegel's most frequent co-investors on Lounge are Jump Trading (1 deal), Menlo Ventures (1 deal), Jeffrey Dean (1 deal), General Catalyst (1 deal) and Michael Carbin (1 deal).

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